Role of p110a subunit of PI3-kinase in skeletal muscle mitochondrial homeostasis and metabolism-Reference-Cited by-同舟云学术

Role of p110a subunit of PI3-kinase in skeletal muscle mitochondrial homeostasis and metabolism

Published:2019-07-30 Issue:1 Volume:10 Page:
ISSN:2041-1723
Container-title:Nature Communications
language:en
Short-container-title:Nat Commun

Author:

Li Mengyao Ella,Lauritzen Hans P. M. M.,O’Neill Brian T.,Wang Chih-Hao,Cai Weikang,Brandao Bruna B.,Sakaguchi Masaji,Tao Rongya,Hirshman Michael F.,Softic Samir,Kahn C. Ronald

Funder

U.S. Department of Health & Human Services | NIH | National Center for Research Resources

Publisher

Springer Science and Business Media LLC

Subject

General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry

Link

http://www.nature.com/articles/s41467-019-11265-y.pdf

Reference66 articles.

1. Taniguchi, C. M. et al. Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKClambda/zeta. Cell Metab. 3, 343–353 (2006).

2. Sopasakis, V. R. et al. Specific roles of the p110alpha isoform of phosphatidylinsositol 3-kinase in hepatic insulin signaling and metabolic regulation. Cell Metab. 11, 220–230 (2010).

3. Jia, S. et al. Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis. Nature 454, 776–779 (2008).

4. Nelson, V. L., Jiang, Y. P., Dickman, K. G., Ballou, L. M. & Lin, R. Z. Adipose tissue insulin resistance due to loss of PI3K p110alpha leads to decreased energy expenditure and obesity. Am. J. Physiol. Endocrinol. Metab. 306, E1205–E1216 (2014).

5. DeFronzo, R. A. & Tripathy, D. Skeletal muscle insulin resistance is the primary defect in type 2 diabetes. Diabetes Care 32(Suppl 2), S157–S163 (2009).

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