Antipsychotics with similar association kinetics at dopamine D2 receptors differ in extrapyramidal side-effects
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry
Link
http://www.nature.com/articles/s41467-018-04489-x.pdf
Reference11 articles.
1. Sykes, D. A. et al. Extrapyramidal side effects of antipsychotics are linked to their association kinetics at dopamine D2 receptors. Nat. Commun. 8, 763 (2017).
2. Sahlholm, K. et al. The fast-off hypothesis revisited: A functional kinetic study of antipsychotic antagonism of the dopamine D2 receptor. Eur. Neuropsychopharmacol. 26, 467–476 (2016).
3. Lewander, T., Westerbergh, S. E. & Morrison, D. Clinical profile of remoxipride--a combined analysis of a comparative double-blind multicentre trial programme. Acta Psychiatr. Scand. Suppl. 358, 92–98 (1990).
4. Bymaster, F. P. et al. Radioreceptor binding profile of the atypical antipsychotic olanzapine. Neuropsychopharmacology 14, 87–96 (1996).
5. Bymaster, F. P. et al. Muscarinic mechanisms of antipsychotic atypicality. Prog. Neuropsychopharmacol. Biol. Psychiatry 27, 1125–1143 (2003).
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