A biased ligand for OXE-R uncouples Gα and Gβγ signaling within a heterotrimer-Reference-Cited by-同舟云学术

A biased ligand for OXE-R uncouples Gα and Gβγ signaling within a heterotrimer

Published:2012-05-27 Issue:7 Volume:8 Page:631-638
ISSN:1552-4450
Container-title:Nature Chemical Biology
language:en
Short-container-title:Nat Chem Biol

Author:

Blättermann Stefanie,Peters Lucas,Ottersbach Philipp Aaron,Bock Andreas,Konya Viktoria,Weaver C David,Gonzalez Angel,Schröder Ralf,Tyagi Rahul,Luschnig Petra,Gäb Jürgen,Hennen Stephanie,Ulven Trond,Pardo Leonardo,Mohr Klaus,Gütschow Michael,Heinemann Akos,Kostenis Evi

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Molecular Biology

Link

http://www.nature.com/articles/nchembio.962.pdf

Reference48 articles.

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3. Rasmussen, S.G.F. et al. Structure of a nanobody-stabilized active state of the β2 adrenoceptor. Nature 469, 175–180 (2011).

4. Warne, T. et al. The structural basis for agonist and partial agonist action on a β1-adrenergic receptor. Nature 469, 241–244 (2011).

5. Kenakin, T. & Miller, L.J. Seven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery. Pharmacol. Rev. 62, 265–304 (2010).

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