Quantitating drug-target engagement in single cells in vitro and in vivo-Reference-Cited by-同舟云学术

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Quantitating drug-target engagement in single cells in vitro and in vivo

Published:2016-12-05 Issue:2 Volume:13 Page:168-173
ISSN:1552-4450
Container-title:Nature Chemical Biology
language:en
Short-container-title:Nat Chem Biol

Author:

Dubach J Matthew,Kim Eunha,Yang Katherine,Cuccarese Michael,Giedt Randy J,Meimetis Labros G,Vinegoni Claudio,Weissleder Ralph

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Molecular Biology

Link

http://www.nature.com/articles/nchembio.2248.pdf

Reference43 articles.

1. Bunnage, M.E., Chekler, E.L. & Jones, L.H. Target validation using chemical probes. Nat. Chem. Biol. 9, 195–199 (2013).

2. Morgan, P. et al. Can the flow of medicines be improved? Fundamental pharmacokinetic and pharmacological principles toward improving Phase II survival. Drug Discov. Today 17, 419–424 (2012).

3. Smith, D.A., Di, L. & Kerns, E.H. The effect of plasma protein binding on in vivo efficacy: misconceptions in drug discovery. Nat. Rev. Drug Discov. 9, 929–939 (2010).

4. Mateo, J., Ong, M., Tan, D.S., Gonzalez, M.A. & de Bono, J.S. Appraising iniparib, the PARP inhibitor that never was–what must we learn? Nat. Rev. Clin. Oncol. 10, 688–696 (2013).

5. Cohen, M.S., Hadjivassiliou, H. & Taunton, J. A clickable inhibitor reveals context-dependent autoactivation of p90 RSK. Nat. Chem. Biol. 3, 156–160 (2007).

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