Human ophthalmic artery as a sensor for non-invasive intracranial pressure monitoring: numerical modeling and in vivo pilot study

Author:

Lucinskas Paulius,Deimantavicius Mantas,Bartusis LaimonasORCID,Zakelis RolandasORCID,Misiulis EdgarasORCID,Dziugys AlgisORCID,Hamarat YasinORCID

Abstract

AbstractIntracranial pressure (ICP) monitoring is important in managing neurosurgical, neurological, and ophthalmological patients with open-angle glaucoma. Non-invasive two-depth transcranial Doppler (TCD) technique is used in a novel method for ICP snapshot measurement that has been previously investigated prospectively, and the results showed clinically acceptable accuracy and precision. The aim of this study was to investigate possibility of using the ophthalmic artery (OA) as a pressure sensor for continuous ICP monitoring. First, numerical modeling was done to investigate the possibility, and then a pilot clinical study was conducted to compare two-depth TCD-based non-invasive ICP monitoring data with readings from an invasive Codman ICP microsensor from patients with severe traumatic brain injury. The numerical modeling showed that the systematic error of non-invasive ICP monitoring was < 1.0 mmHg after eliminating the intraorbital and blood pressure gradient. In a clinical study, a total of 1928 paired data points were collected, and the extreme data points of measured differences between invasive and non-invasive ICP were − 3.94 and 4.68 mmHg (95% CI − 2.55 to 2.72). The total mean and SD were 0.086 ± 1.34 mmHg, and the correlation coefficient was 0.94. The results show that the OA can be used as a linear natural pressure sensor and that it could potentially be possible to monitor the ICP for up to 1 h without recalibration.

Funder

Lietuvos Mokslo Taryba

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Reference46 articles.

1. Abdelsadg, M. et al. Intra cranial pressure (ICP) monitoring in traumatic brain injury; what is the evidence?. Open Access J. Neurol. Neurosurg. 5, 555672 (2017).

2. Carney, N. et al. Guidelines for the management of severe traumatic brain injury, fourth edition. Neurosurgery 80, 6–15 (2017).

3. Zacchetti, L., Magnoni, S., Di Corte, F., Zanier, E. R. & Stocchetti, N. Accuracy of intracranial pressure monitoring: Systematic review and meta-analysis. Crit. Care 19, 420 (2015).

4. Akbik, O. S., Carlson, A. P. & Yonas, H. The roles of ventricular and parenchymal intracranial pressure monitoring. Curr. Neurobiol. 07, 1–6 (2016).

5. Tham, Y.-C. et al. Global prevalence of glaucoma and projections of glaucoma burden through 2040: A systematic review and meta-analysis. Ophthalmology 121, 2081–2090 (2014).

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