Author:
Zahed Hana,Johansson Mattias,Ueland Per M.,Midttun Øivind,Milne Roger L.,Giles Graham G.,Manjer Jonas,Sandsveden Malte,Langhammer Arnulf,Sørgjerd Elin Pettersen,Grankvist Kjell,Johansson Mikael,Freedman Neal D.,Huang Wen-Yi,Chen Chu,Prentice Ross,Stevens Victoria L.,Wang Ying,Le Marchand Loic,Wilkens Lynne R.,Weinstein Stephanie J.,Albanes Demetrius,Cai Qiuyin,Blot William J.,Arslan Alan A.,Zeleniuch-Jacquotte Anne,Shu Xiao-Ou,Zheng Wei,Yuan Jian-Min,Koh Woon-Puay,Visvanathan Kala,Sesso Howard D.,Zhang Xuehong,Gaziano J. Michael,Fanidi Anouar,Muller David,Brennan Paul,Guida Florence,Robbins Hilary A.
Abstract
AbstractImbalances of blood biomarkers are associated with disease, and biomarkers may also vary non-pathologically across population groups. We described variation in concentrations of biomarkers of one-carbon metabolism, vitamin status, inflammation including tryptophan metabolism, and endothelial and renal function among cancer-free older adults. We analyzed 5167 cancer-free controls aged 40–80 years from 20 cohorts in the Lung Cancer Cohort Consortium (LC3). Centralized biochemical analyses of 40 biomarkers in plasma or serum were performed. We fit multivariable linear mixed effects models to quantify variation in standardized biomarker log-concentrations across four factors: age, sex, smoking status, and body mass index (BMI). Differences in most biomarkers across most factors were small, with 93% (186/200) of analyses showing an estimated difference lower than 0.25 standard-deviations, although most were statistically significant due to large sample size. The largest difference was for creatinine by sex, which was − 0.91 standard-deviations lower in women than men (95%CI − 0.98; − 0.84). The largest difference by age was for total cysteine (0.40 standard-deviation increase per 10-year increase, 95%CI 0.36; 0.43), and by BMI was for C-reactive protein (0.38 standard-deviation increase per 5-kg/m2 increase, 95%CI 0.34; 0.41). For 31 of 40 markers, the mean difference between current and never smokers was larger than between former and never smokers. A statistically significant (p < 0.05) association with time since smoking cessation was observed for 8 markers, including C-reactive protein, kynurenine, choline, and total homocysteine. We conclude that most blood biomarkers show small variations across demographic characteristics. Patterns by smoking status point to normalization of multiple physiological processes after smoking cessation.
Publisher
Springer Science and Business Media LLC