Author:
Bikia Vasiliki,Papaioannou Theodore G.,Pagoulatou Stamatia,Rovas Georgios,Oikonomou Evangelos,Siasos Gerasimos,Tousoulis Dimitris,Stergiopulos Nikolaos
Abstract
AbstractCardiac and aortic characteristics are crucial for cardiovascular disease detection. However, noninvasive estimation of aortic hemodynamics and cardiac contractility is still challenging. This paper investigated the potential of estimating aortic systolic pressure (aSBP), cardiac output (CO), and end-systolic elastance (Ees) from cuff-pressure and pulse wave velocity (PWV) using regression analysis. The importance of incorporating ejection fraction (EF) as additional input for estimating Ees was also assessed. The models, including Random Forest, Support Vector Regressor, Ridge, Gradient Boosting, were trained/validated using synthetic data (n = 4,018) from an in-silico model. When cuff-pressure and PWV were used as inputs, the normalized-RMSEs/correlations for aSBP, CO, and Ees (best-performing models) were 3.36 ± 0.74%/0.99, 7.60 ± 0.68%/0.96, and 16.96 ± 0.64%/0.37, respectively. Using EF as additional input for estimating Ees significantly improved the predictions (7.00 ± 0.78%/0.92). Results showed that the use of noninvasive pressure measurements allows estimating aSBP and CO with acceptable accuracy. In contrast, Ees cannot be predicted from pressure signals alone. Addition of the EF information greatly improves the estimated Ees. Accuracy of the model-derived aSBP compared to in-vivo aSBP (n = 783) was very satisfactory (5.26 ± 2.30%/0.97). Future in-vivo evaluation of CO and Ees estimations remains to be conducted. This novel methodology has potential to improve the noninvasive monitoring of aortic hemodynamics and cardiac contractility.
Publisher
Springer Science and Business Media LLC
Reference89 articles.
1. Waddell, T. K., Dart, A. M., Medley, T. L., Cameron, J. D. & Kingwell, B. A. Carotid pressure is a better predictor of coronary artery disease severity than brachial pressure. Hypertension 38, 927–931 (2001).
2. Safar, M. E. et al. Central pulse pressure and mortality in end-stage renal disease. Hypertension 39, 735–738 (2002).
3. Berkenstadt, H. et al. Stroke volume variation as a predictor of fluid responsiveness in patients undergoing brain surgery. Anesth. Analg. 92, 984–989 (2001).
4. Sagawa, K., Suga, H., Shoukas, A. A. & Bakalar, K. M. End-systolic pressure/volume ratio: a new index of ventricular contractility. Am. J. Cardiol. 40, 748–753 (1977).
5. Song-Tao, A., Yan-Yan, Q. & Li-Xia, W. The severity of coronary artery disease evaluated by central systolic pressure and fractional diastolic pressure. N. Am. J. Med. Sci. 2, 218–220 (2010).
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