Targeted insertion of an anti-CD2 monoclonal antibody transgene into the GGTA1 locus in pigs using FokI-dCas9-Reference-Cited by-同舟云学术

Targeted insertion of an anti-CD2 monoclonal antibody transgene into the GGTA1 locus in pigs using FokI-dCas9

Published:2017-08-16 Issue:1 Volume:7 Page:
ISSN:2045-2322
Container-title:Scientific Reports
language:en
Short-container-title:Sci Rep

Author:

Nottle Mark B.,Salvaris Evelyn J.,Fisicaro Nella,McIlfatrick Stephen,Vassiliev Ivan,Hawthorne Wayne J.,O’Connell Philip J.,Brady Jamie L.,Lew Andrew M.,Cowan Peter J.^ORCID

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/s41598-017-09030-6.pdf

Reference28 articles.

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2. Cowan, P. J. et al. Renal xenografts from triple-transgenic pigs are not hyperacutely rejected but cause coagulopathy in non-immunosuppressed baboons. Transplantation 69, 2504–2515 (2000).

3. Mohiuddin, M. M. et al. Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft. Nature communications 7, 11138, doi: 10.1038/ncomms11138 (2016).

4. Brady, J. L. et al. Monoclonal antibodies generated by DNA immunization recognize CD2 from a broad range of primates. Immunol Cell Biol 87, 413–418 (2009).

5. Brady, J. L. et al. Anti-CD2 producing pig xenografts effect localized depletion of human T cells in a huSCID model. Xenotransplantation 20, 100–109 (2013).

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