Porcine embryonic stem cells: An alternative solution for the shortage of human islets to treat type 1 diabetes?-Reference-Cited by-同舟云学术

Porcine embryonic stem cells: An alternative solution for the shortage of human islets to treat type 1 diabetes?

Published:2024-01 Issue:1 Volume:31 Page:
ISSN:0908-665X
Container-title:Xenotransplantation
language:en
Short-container-title:Xenotransplantation

Author:

Nottle Mark B.¹^ORCID,Vassiliev Ivan¹,Hawthorne Wayne J.²³^ORCID,Cowan Peter J.⁴⁵^ORCID

Affiliation:

1. Robinson Research Institute and School of Biomedicine The University of Adelaide Adelaide South Australia Australia

2. The Centre for Transplant & Renal Research Westmead Institute for Medical Research Westmead New South Wales Australia

3. Department of Surgery Westmead Hospital, School of Medical Sciences University of Sydney Westmead New South Wales Australia

4. Immunology Research Centre St. Vincent's Hospital Melbourne Victoria Australia

5. Department of Medicine University of Melbourne Melbourne Victoria Australia

Abstract

AbstractTransplantation of human embryonic stem cell (ESC) derived beta‐like cells and xenotransplantation of porcine islets are two potential cures for type 1 diabetes (T1D). We have previously reported the isolation of porcine ESCs and have also separately shown that islets from genetically modified pigs can effectively cure diabetes in a preclinical baboon model. Here we discuss the possibility of combining these technologies to produce gene‐edited porcine ESC‐derived islets as an alternative for treating T1D, which may offer several advantages compared with these approaches.

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/xen.12840

Reference20 articles.

1. A Stem Cell Approach to Cure Type 1 Diabetes

2. Emerging diabetes therapies: Bringing back the β-cells

3. Report of the Key Opinion Leaders Meeting on Stem Cell-derived Beta Cells

4. Xenogeneic transplantation and tolerance in the era of CRISPR-Cas9

5. Xenotransplantation and interspecies organogenesis: current status and issues