Imatinib reduces non-alcoholic fatty liver disease in obese mice by targeting inflammatory and lipogenic pathways in macrophages and liver-Reference-Cited by-同舟云学术

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Imatinib reduces non-alcoholic fatty liver disease in obese mice by targeting inflammatory and lipogenic pathways in macrophages and liver

Published:2018-10-17 Issue:1 Volume:8 Page:
ISSN:2045-2322
Container-title:Scientific Reports
language:en
Short-container-title:Sci Rep

Author:

AlAsfoor Shefaa,Rohm Theresa V.,Bosch Angela J. T.,Dervos Thomas,Calabrese Diego,Matter Matthias S.,Weber Achim,Cavelti-Weder Claudia

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/s41598-018-32853-w.pdf

Reference50 articles.

1. Tilg, H., Moschen, A. R. & Roden, M. NAFLD and diabetes mellitus. Nat Rev Gastroenterol Hepatol 14, 32–42, https://doi.org/10.1038/nrgastro.2016.147 (2017).

2. Tosello-Trampont, A. C., Landes, S. G., Nguyen, V., Novobrantseva, T. I. & Hahn, Y. S. Kuppfer cells trigger nonalcoholic steatohepatitis development in diet-induced mouse model through tumor necrosis factor-alpha production. J Biol Chem 287, 40161–40172, https://doi.org/10.1074/jbc.M112.417014 (2012).

3. Tacke, F. Targeting hepatic macrophages to treat liver diseases. J Hepatol 66, 1300–1312, https://doi.org/10.1016/j.jhep.2017.02.026 (2017).

4. Baeck, C. et al. Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury. Gut 61, 416–426, https://doi.org/10.1136/gutjnl-2011-300304 (2012).

5. Krenkel, O. & Tacke, F. Liver macrophages in tissue homeostasis and disease. Nat Rev Immunol 17, 306–321, https://doi.org/10.1038/nri.2017.11 (2017).

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