The ability to utilise ammonia as nitrogen source is cell type specific and intricately linked to GDH, AMPK and mTORC1
Author:
Funder
Cancer Council South Australia
Worldwide Cancer Research
Flinders Foundation https://www.flindersfoundation.org.au/
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/s41598-018-37509-3.pdf
Reference40 articles.
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2. Weisman, R. Target of Rapamycin (TOR) Regulates Growth in Response to Nutritional Signals. Microbiol Spectr 4 (2016).
3. Bar-Peled, L. & Sabatini, D. M. Regulation of mTORC1 by amino acids. Trends Cell Biol 24, 400–406 (2014).
4. Stracka, D., Jozefczuk, S., Rudroff, F., Sauer, U. & Hall, M. N. Nitrogen source activates TOR (target of rapamycin) complex 1 via glutamine and independently of Gtr/Rag proteins. J Biol Chem 289, 25010–25020 (2014).
5. Tardito, S. et al. Glutamine Synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma. Nat Cell Biol 17, 1556–1568 (2015).
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