Pyrimidine nucleotide starvation induces a decrease in the number of effector T cells but not memory T cells
Author:
Funder
Seoul National University
National Research Foundation of Korea
Publisher
Springer Science and Business Media LLC
Subject
Infectious Diseases,Immunology,Immunology and Allergy
Link
https://www.nature.com/articles/s41423-023-01014-z.pdf
Reference8 articles.
1. Scherer S, Oberle SG, Kanev K, Gerullis AK, Wu M, de Almeida GP, et al. Pyrimidine de novo synthesis inhibition selectively blocks effector but not memory T cell development. Nat Immunol. 2023;24:501–15.
2. Klotz L, Eschborn M, Lindner M, Liebmann M, Herold M, Janoschka C, et al. Teriflunomide treatment for multiple sclerosis modulates T cell mitochondrial respiration with affinity-dependent effects. Sci Transl Med. 2019;11:eaao5563.
3. Peeters MJW, Aehnlich P, Pizzella A, Molgaard K, Seremet T, Met O, et al. Mitochondrial-Linked de novo pyrimidine biosynthesis dictates human T-cell proliferation but not expression of effector molecules. Front Immunol. 2021;12:718863.
4. Ozturk S, Mathur D, Zhou RW, Mulholland D, Parsons R. Leflunomide triggers synthetic lethality in PTEN-deficient prostate cancer. Prostate Cancer Prostatic Dis. 2020;23:718–23.
5. Joshi NS, Cui W, Chandele A, Lee HK, Urso DR, Hagman J, et al. Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor. Immunity. 2007;27:281–95.
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