Teriflunomide treatment for multiple sclerosis modulates T cell mitochondrial respiration with affinity-dependent effects

Author:

Klotz Luisa1ORCID,Eschborn Melanie1ORCID,Lindner Maren1ORCID,Liebmann Marie1ORCID,Herold Martin1ORCID,Janoschka Claudia1ORCID,Torres Garrido Belén1ORCID,Schulte-Mecklenbeck Andreas1,Gross Catharina C.1ORCID,Breuer Johanna1,Hundehege Petra1ORCID,Posevitz Vilmos1,Pignolet Béatrice2ORCID,Nebel Giulia3,Glander Shirin4,Freise Nicole5ORCID,Austermann Judith5,Wirth Timo1,Campbell Graham R.6ORCID,Schneider-Hohendorf Tilman1ORCID,Eveslage Maria7ORCID,Brassat David2ORCID,Schwab Nicholas1ORCID,Loser Karin8,Roth Johannes5,Busch Karin B.3,Stoll Monika49ORCID,Mahad Don J.6,Meuth Sven G.1ORCID,Turner Timothy10ORCID,Bar-Or Amit11,Wiendl Heinz112

Affiliation:

1. University Hospital Münster, Department of Neurology with Institute of Translational Neurology, 48149 Münster, Germany.

2. CRC-SEP, Neurosciences Department, Toulouse University Hospital and INSERM U1043 - CNRS UMR 5282, Centre de Physiopathologie Toulouse-Purpan, Université Toulouse III, 31300 Toulouse, France.

3. University of Münster, Institute of Molecular Cell Biology, 48149 Münster, Germany.

4. University of Münster, Department of Genetic Epidemiology, 48149 Münster, Germany.

5. University of Münster, Department of Immunology, 48149 Münster, Germany.

6. University of Edinburgh, Centre for Clinical Brain Sciences, EH8 9YL Edinburgh, UK.

7. University of Münster, Institute of Biostatistics and Clinical Research, 48149 Münster, Germany.

8. University Hospital Münster, Department of Dermatology, 48149 Münster, Germany.

9. Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, 6229 ER Maastricht, Netherlands.

10. Sanofi Genzyme, Cambridge, MA 02142, USA.

11. Center for Neuroinflammation and Experimental Therapeutics and Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

12. Brain and Mind Centre, Medical Faculty, University of Sydney, Sydney, Camperdown, NSW 2050, Australia.

Abstract

Inhibition of a mitochondrial enzyme during multiple sclerosis treatment modulates antigen-specific T cell responses in an affinity-dependent fashion.

Funder

Deutsche Forschungsgemeinschaft

Interdisziplinäres Zentrum für Klinische Forschung (IZKF), Münster

Sanofi Genzyme

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3