Nonallele-specific Silencing of Mutant and Wild-type Huntingtin Demonstrates Therapeutic Efficacy in Huntington's Disease Mice-Reference-Cited by-同舟云学术

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Nonallele-specific Silencing of Mutant and Wild-type Huntingtin Demonstrates Therapeutic Efficacy in Huntington's Disease Mice

Published:2009-06 Issue:6 Volume:17 Page:1053-1063
ISSN:1525-0016
Container-title:Molecular Therapy
language:en
Short-container-title:Molecular Therapy

Author:

Boudreau Ryan L,McBride Jodi L,Martins Inês,Shen Shihao,Xing Yi,Carter Barrie J,Davidson Beverly L

Publisher

Elsevier BV

Subject

Drug Discovery,Pharmacology,Genetics,Molecular Biology,Molecular Medicine

Reference50 articles.

1. Cellular toxicity of polyglutamine expansion proteins: mechanism of transcription factor deactivation;Schaffar;Mol Cell,2004

2. Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions;Saudou;Cell,1998

3. Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes;Zuccato;Nat Genet,2003

4. In vitro analysis of huntingtin-mediated transcriptional repression reveals multiple transcription factor targets;Zhai;Cell,2005

5. Sp1 is up-regulated in cellular and transgenic models of Huntington disease, and its reduction is neuroprotective;Qiu;J Biol Chem,2006

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