DRP1 inhibition rescues retinal ganglion cells and their axons by preserving mitochondrial integrity in a mouse model of glaucoma-Reference-Cited by-同舟云学术

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DRP1 inhibition rescues retinal ganglion cells and their axons by preserving mitochondrial integrity in a mouse model of glaucoma

Published:2015-08 Issue:8 Volume:6 Page:e1839-e1839
ISSN:2041-4889
Container-title:Cell Death & Disease
language:en
Short-container-title:Cell Death Dis

Author:

Kim K-Y,Perkins G A,Shim M S,Bushong E,Alcasid N,Ju S,Ellisman M H,Weinreb R N,Ju W-K

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Cell Biology,Cellular and Molecular Neuroscience,Immunology

Link

http://www.nature.com/articles/cddis2015180.pdf

Reference65 articles.

1. Ju WK, Kim KY, Lindsey JD, Angert M, Duong-Polk KX, Scott RT et al. Intraocular pressure elevation induces mitochondrial fission and triggers OPA1 release in glaucomatous optic nerve. Invest Ophthalmol Vis Sci 2008; 49: 4903–4911.

2. Knott AB, Perkins G, Schwarzenbacher R, Bossy-Wetzel E . Mitochondrial fragmentation in neurodegeneration. Nat Rev Neurosci 2008; 9: 505–518.

3. Song W, Chen J, Petrilli A, Liot G, Klinglmayr E, Zhou Y et al. Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity. Nat Med 2011; 17: 377–382.

4. Guo X, Disatnik MH, Monbureau M, Shamloo M, Mochly-Rosen D, Qi X . Inhibition of mitochondrial fragmentation diminishes Huntington's disease-associated neurodegeneration. J Clin Invest 2013; 123: 5371–5388.

5. Burte F, Carelli V, Chinnery PF, Yu-Wai-Man P . Disturbed mitochondrial dynamics and neurodegenerative disorders. Nat Rev Neurol 2015; 11: 11–24.

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