Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity-Reference-Cited by-同舟云学术

Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity

Published:2011-02-20 Issue:3 Volume:17 Page:377-382
ISSN:1078-8956
Container-title:Nature Medicine
language:en
Short-container-title:Nat Med

Author:

Song Wenjun,Chen Jin,Petrilli Alejandra,Liot Geraldine,Klinglmayr Eva,Zhou Yue,Poquiz Patrick,Tjong Jonathan,Pouladi Mahmoud A,Hayden Michael R,Masliah Eliezer,Ellisman Mark,Rouiller Isabelle,Schwarzenbacher Robert,Bossy Blaise,Perkins Guy,Bossy-Wetzel Ella

Publisher

Springer Science and Business Media LLC

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

http://www.nature.com/articles/nm.2313.pdf

Reference33 articles.

1. Bossy-Wetzel, E., Petrilli, A. & Knott, A.B. Mutant huntingtin and mitochondrial dysfunction. Trends Neurosci. 31, 609–616 (2008).

2. Lin, M.T. & Beal, M.F. Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature 443, 787–795 (2006).

3. Knott, A.B. & Bossy-Wetzel, E. Impairing the mitochondrial fission and fusion balance: a new mechanism of neurodegeneration. Ann. NY Acad. Sci. 1147, 283–292 (2008).

4. Knott, A.B., Perkins, G., Schwarzenbacher, R. & Bossy-Wetzel, E. Mitochondrial fragmentation in neurodegeneration. Nat. Rev. Neurosci. 9, 505–518 (2008).

5. Chen, H. et al. Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development. J. Cell Biol. 160, 189–200 (2003).

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