Author:
Hartenstein Volker,Giangrande Angela
Abstract
AbstractDespite their great importance for biomedical research, the intricate network of relationships between macro- and microglia, in terms of development, function and evolution, remains poorly understood. Drawing inspiration from the recent meeting “Of Glia and Microglia”, held at the University of Strasbourg in December 2017, we here discuss the outstanding questions in the seemingly disparate fields of glial development, physiology and evolution, and also provide suggestions for how the field should move forward.
Publisher
Springer Science and Business Media LLC
Subject
General Agricultural and Biological Sciences,General Biochemistry, Genetics and Molecular Biology,Medicine (miscellaneous)
Reference25 articles.
1. Yin, J., Valin, K. L., Dixon, M. L. & Leavenworth, J. W. The role of microglia and macrophages in CNS homeostasis, autoimmunity, and cancer. J. Immunol. Res 2017, 5150678 (2017).
2. Zuchero, J. B. & Barres, B. A. Glia in mammalian development and disease. Development 142, 3805–3809 (2015).
3. Chung, W. S. et al. Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways. Nature 504, 394–400 (2013).
4. Gascon, S., Masserdotti, G., Russo, G. L. & Gotz, M. Direct neuronal reprogramming: achievements, hurdles, and new roads to success. Cell Stem Cell 21, 18–34 (2017).
5. Ginhoux, F. et al. Fate mapping analysis reveals that adult microglia derive from primitive macrophages. Science 330, 841–845 (2010).
Cited by
24 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献