Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages-Reference-Cited by-同舟云学术

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

Published:2010-11-05 Issue:6005 Volume:330 Page:841-845
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Ginhoux Florent¹²,Greter Melanie¹,Leboeuf Marylene¹,Nandi Sayan³,See Peter²,Gokhan Solen⁴,Mehler Mark F.⁴⁵,Conway Simon J.⁶,Ng Lai Guan²,Stanley E. Richard³,Samokhvalov Igor M.⁷,Merad Miriam¹

Affiliation:

1. Department of Gene and Cell Medicine and the Immunology Institute, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA.

2. Singapore Immunology Network (SIgN), 8A Biomedical Grove, IMMUNOS Building Nos. 3-4, BIOPOLIS, 138648, Singapore.

3. Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.

4. Institute for Brain Disorders and Neural Regeneration, Rose F. Kennedy Center for Research on Intellectual and Developmental Disabilities, and Department of Neurology, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, NY 10461, USA.

5. Departments of Neuroscience, Psychiatry, and Behavioral Sciences, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, NY 10461, USA.

6. Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, 1044 West Walnut Street, Indianapolis, IN 46202, USA.

7. Laboratory for Stem Cell Biology, Center for Developmental Biology (CDB), RIKEN Kobe, Kobe 6500047, Japan.

Abstract

Primitive Origins for Microglia Microglia are the resident macrophages of the central nervous system and are associated with neurodegeneration and brain inflammatory diseases. Although the developmental origins of other tissue macrophage populations are well established, the origins of microglia remain controversial. Ginhoux et al. (p. 841 , published online 21 October) used in vivo lineage tracing studies to show that microglia arise early in mouse development and derive from primitive macrophages in the yolk sac. This is in contrast to other cells of the mononuclear phagocyte system, which arise later in development from a distinct progenitor population.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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