Safety and efficacy of novel malaria vaccine regimens of RTS,S/AS01B alone, or with concomitant ChAd63-MVA-vectored vaccines expressing ME-TRAP-Reference-Cited by-同舟云学术

Safety and efficacy of novel malaria vaccine regimens of RTS,S/AS01B alone, or with concomitant ChAd63-MVA-vectored vaccines expressing ME-TRAP

Published:2018-10-09 Issue:1 Volume:3 Page:
ISSN:2059-0105
Container-title:npj Vaccines
language:en
Short-container-title:npj Vaccines

Author:

Rampling Tommy^ORCID,Ewer Katie J.^ORCID,Bowyer Georgina^ORCID,Edwards Nick J.,Wright Danny,Sridhar Saranya,Payne Ruth,Powlson Jonathan,Bliss Carly,Venkatraman Navin,Poulton Ian D.,de Graaf Hans,Gbesemete Diane,Grobbelaar Amy,Davies Huw,Roberts Rachel,Angus Brian,Ivinson Karen,Weltzin Rich,Rajkumar Bebi-Yassin,Wille-Reece Ulrike,Lee Cynthia,Ockenhouse Chris,Sinden Robert E.,Gerry Stephen C.,Lawrie Alison M.,Vekemans Johan,Morelle Danielle,Lievens Marc,Ballou Ripley W.,Lewis David J. M.,Cooke Graham S.,Faust Saul N.^ORCID,Gilbert Sarah,Hill Adrian V. S^ORCID

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Infectious Diseases,Pharmacology,Immunology

Link

http://www.nature.com/articles/s41541-018-0084-2.pdf

Reference27 articles.

1. WHO. World Malaria Report 2017 (WHO, Geneva, Switzerland, 2017).

2. Ewer, K. J. et al. Protective CD8+ T-cell immunity to human malaria induced by chimpanzee adenovirus-MVA immunisation. Nat. Commun. 4, 2836 (2013).

3. Kester, K. E. et al. Randomized, double-blind, phase 2a trial of falciparum malaria vaccines RTS,S/AS01B and RTS,S/AS02A in malaria-naive adults: safety, efficacy, and immunologic associates of protection. J. Infect. Dis. 200, 337–346 (2009).

4. Seder, R. A. et al. Protection against malaria by intravenous immunization with a nonreplicating sporozoite vaccine. Science 341, 1359–1365 (2013).

5. Stoute, J. A. et al. A preliminary evaluation of a recombinant circumsporozoite protein vaccine against Plasmodium falciparum malaria. RTS,S Malaria Vaccine Evaluation Group. N. Engl. J. Med 336, 86–91 (1997).

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