Coimmunization with Preerythrocytic Antigens alongside Circumsporozoite Protein Can Enhance Sterile Protection against <i>Plasmodium</i> Sporozoite Infection-Reference-Cited by-同舟云学术

Coimmunization with Preerythrocytic Antigens alongside Circumsporozoite Protein Can Enhance Sterile Protection against Plasmodium Sporozoite Infection

Published:2023-04-13 Issue:2 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Vigdorovich Vladimir¹^ORCID,Patel Hardik¹^ORCID,Watson Alexander¹,Raappana Andrew¹,Reynolds Laura¹,Selman William¹,Beeman Suzannah¹,Edlefsen Paul T.²,Kappe Stefan H. I.¹³⁴,Sather D. Noah¹³⁴^ORCID

Affiliation:

1. Center for Global Infectious Disease Research, Seattle Children’s Research Institute, Seattle, Washington, USA

2. Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

3. Department of Pediatrics, University of Washington, Seattle, Washington, USA

4. Department of Global Health, University of Washington, Seattle, Washington, USA

Abstract

The currently approved malaria vaccine targets a single parasite protein (CSP) and results in only partial protection. We tested several additional vaccine targets in combination with CSP to identify those that could enhance protection from infection upon challenge in the mouse malaria model.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.03791-22

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