Globally reduced N6-methyladenosine (m6A) in C9ORF72-ALS/FTD dysregulates RNA metabolism and contributes to neurodegeneration-Reference-Cited by-同舟云学术

Globally reduced N6-methyladenosine (m6A) in C9ORF72-ALS/FTD dysregulates RNA metabolism and contributes to neurodegeneration

Published:2023-06-26 Issue:8 Volume:26 Page:1328-1338
ISSN:1097-6256
Container-title:Nature Neuroscience
language:en
Short-container-title:Nat Neurosci

Author:

Li Yini^ORCID,Dou Xiaoyang,Liu Jun,Xiao Yu,Zhang Zhe,Hayes Lindsey^ORCID,Wu Rong,Fu Xiujuan,Ye Yingzhi,Yang Bing,Ostrow Lyle W.^ORCID,He Chuan^ORCID,Sun Shuying^ORCID

Funder

U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke

U.S. Department of Health & Human Services | NIH | National Institute on Aging

Muscular Dystrophy Association

U.S. Department of Health & Human Services | NIH | National Human Genome Research Institute

U.S. Department of Health & Human Services | NIH | National Institute of Environmental Health Sciences

Publisher

Springer Science and Business Media LLC

Subject

General Neuroscience

Link

https://www.nature.com/articles/s41593-023-01374-9.pdf

Reference71 articles.

1. Nussbacher, J. K., Tabet, R., Yeo, G. W. & Lagier-Tourenne, C. Disruption of RNA metabolism in neurological diseases and emerging therapeutic interventions. Neuron 102, 294–320 (2019).

2. Ferrari, R., Kapogiannis, D., Huey, E. D. & Momeni, P. FTD and ALS: a tale of two diseases. Curr. Alzheimer Res. 8, 273–294 (2011).

3. Ito, D., Hatano, M. & Suzuki, N. RNA binding proteins and the pathological cascade in ALS/FTD neurodegeneration. Sci. Transl. Med. 9, eaah5436 (2017).

4. Freibaum, B. D. & Taylor, J. P. The role of dipeptide repeats in C9ORF72-related ALS-FTD. Front. Mol. Neurosci. 10, 35 (2017).

5. Cheng, W. et al. CRISPR–Cas9 screens identify the RNA helicase DDX3X as a repressor of C9ORF72 (GGGGCC)n repeat-associated non-AUG translation. Neuron 104, 885–898 (2019).

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