CRISPR-Cas9 Screens Identify the RNA Helicase DDX3X as a Repressor of C9ORF72 (GGGGCC)n Repeat-Associated Non-AUG Translation-Reference-Cited by-同舟云学术

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CRISPR-Cas9 Screens Identify the RNA Helicase DDX3X as a Repressor of C9ORF72 (GGGGCC)n Repeat-Associated Non-AUG Translation

Published:2019-12 Issue:5 Volume:104 Page:885-898.e8
ISSN:0896-6273
Container-title:Neuron
language:en
Short-container-title:Neuron

Author:

Cheng Weiwei,Wang Shaopeng,Zhang Zhe,Morgens David W.,Hayes Lindsey R.,Lee Soojin,Portz Bede,Xie Yongzhi,Nguyen Baotram V.,Haney Michael S.,Yan Shirui,Dong Daoyuan,Coyne Alyssa N.,Yang Junhua,Xian Fengfan,Cleveland Don W.,Qiu Zhaozhu,Rothstein Jeffrey D.,Shorter James,Gao Fen-Biao,Bassik Michael C.,Sun Shuying

Funder

NIH

Target ALS

Packard Center for ALS Research

ALS Association

Target ALS Foundation

Muscular Dystrophy Association

AAN/ALSA

American Heart Association

BrightFocus Foundation

Publisher

Elsevier BV

Subject

General Neuroscience

Reference73 articles.

1. Unconventional translation of C9ORF72 GGGGCC expansion generates insoluble polypeptides specific to c9FTD/ALS;Ash;Neuron,2013

2. Phase Separation of C9orf72 Dipeptide Repeats Perturbs Stress Granule Dynamics;Boeynaems;Mol. Cell,2017

3. Targeting DDX3 with a small molecule inhibitor for lung cancer therapy;Bol;EMBO Mol. Med.,2015

4. DDX3, a potential target for cancer treatment;Bol;Mol. Cancer,2015

5. C9ORF72 GGGGCC repeat-associated non-AUG translation is upregulated by stress through eIF2α phosphorylation;Cheng;Nat. Commun.,2018

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3. DDX3X overexpression decreases dipeptide repeat proteins in a mouse model of C9ORF72-ALS/FTD;Experimental Neurology;2024-06

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