Abstract
AbstractIt has been suggested that the function of sleep is to actively clear metabolites and toxins from the brain. Enhanced clearance is also said to occur during anesthesia. Here, we measure clearance and movement of fluorescent molecules in the brains of male mice and show that movement is, in fact, independent of sleep and wake or anesthesia. Moreover, we show that brain clearance is markedly reduced, not increased, during sleep and anesthesia.
Funder
Wellcome Trust
RCUK | Biotechnology and Biological Sciences Research Council
UK Dementia Research Institute
Publisher
Springer Science and Business Media LLC
Cited by
10 articles.
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