A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid β-Reference-Cited by-同舟云学术

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid β

Published:2012-08-15 Issue:147 Volume:4 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Iliff Jeffrey J.¹,Wang Minghuan¹²,Liao Yonghong¹,Plogg Benjamin A.¹,Peng Weiguo¹,Gundersen Georg A.³⁴,Benveniste Helene⁵⁶,Vates G. Edward¹,Deane Rashid¹,Goldman Steven A.¹⁷,Nagelhus Erlend A.³⁴,Nedergaard Maiken¹

Affiliation:

1. Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA.

2. Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

3. Centre for Molecular Medicine Norway, Nordic EMBL Partnership, University of Oslo, 0318 Oslo, Norway.

4. Centre for Molecular Biology and Neuroscience, Letten Centre, Institute of Basic Medical Sciences, University of Oslo, 0317 Oslo, Norway.

5. Department of Radiology, Health Science Center, Stony Brook University, Stony Brook, NY 11794, USA.

6. Department of Anesthesiology, Health Science Center, Stony Brook University, Stony Brook, NY 11794, USA.

7. Department of Neurology, University of Rochester Medical Center, Rochester, NY 14642, USA.

Abstract

Cerebrospinal fluid flows through channels around brain blood vessels that are bounded by astrocytic endfeet, mediated by water transport through aquaporin-4.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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