The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans-Reference-Cited by-同舟云学术

The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans

Published:2019-02-22 Issue:6429 Volume:363 Page:880-884
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Holth Jerrah K.¹²^ORCID,Fritschi Sarah K.¹²^ORCID,Wang Chanung¹²^ORCID,Pedersen Nigel P.³⁴^ORCID,Cirrito John R.¹²,Mahan Thomas E.¹²^ORCID,Finn Mary Beth¹²^ORCID,Manis Melissa¹²^ORCID,Geerling Joel C.⁵^ORCID,Fuller Patrick M.⁶,Lucey Brendan P.¹²^ORCID,Holtzman David M.¹²^ORCID

Affiliation:

1. Department of Neurology, Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA.

2. Charles F. and Joanne Knight Alzheimer’s Disease Research Center, Washington University School of Medicine, St. Louis, MO 63110, USA.

3. Department of Neurology, Emory Epilepsy Center, Emory University, Atlanta, GA 30322, USA.

4. Program in Neuroscience, Emory University, Atlanta, GA 30322, USA.

5. Department of Neurology, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA.

6. Department of Neurology, Beth Israel Deaconess Medical Center, Division of Sleep Medicine, Harvard Medical School, Boston, MA 02215, USA.

Abstract

Sleep may protect the brain from AD Two main proteins accumulate in the brain in Alzheimer's disease (AD), β-amyloid (Aβ) and tau. Aβ appears to instigate AD, but tau appears to drive brain damage and cognitive decline. Sleep deprivation is known to increase Aβ acutely and chronically. Now, Holth et al. show that chronic sleep deprivation strongly increases tau acutely over hours and also drives tau pathology spreading in the brains of mice and humans (see the Perspective by Noble and Spires-Jones). Thus, sleep appears to have a direct protective effect on a key protein that drives AD pathology. Science , this issue p. 880 ; see also p. 813

Funder

National Institute on Aging

National Institute of Neurological Disorders and Stroke

National Center for Advancing Translational Sciences

BrightFocus Foundation

Deutsche Forschungsgemeinschaft

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference31 articles.

1. Tau pathology and neurodegeneration