Engineered CRISPR–Cas12a variants with increased activities and improved targeting ranges for gene, epigenetic and base editing-Reference-Cited by-同舟云学术

Engineered CRISPR–Cas12a variants with increased activities and improved targeting ranges for gene, epigenetic and base editing

Published:2019-02-11 Issue:3 Volume:37 Page:276-282
ISSN:1087-0156
Container-title:Nature Biotechnology
language:en
Short-container-title:Nat Biotechnol

Author:

Kleinstiver Benjamin P.^ORCID,Sousa Alexander A.,Walton Russell T.,Tak Y. Esther,Hsu Jonathan Y.,Clement Kendell,Welch Moira M.,Horng Joy E.^ORCID,Malagon-Lopez Jose,Scarfò Irene^ORCID,Maus Marcela V.^ORCID,Pinello Luca,Aryee Martin J.^ORCID,Joung J. Keith

Publisher

Springer Science and Business Media LLC

Subject

Biomedical Engineering,Molecular Medicine,Applied Microbiology and Biotechnology,Bioengineering,Biotechnology

Link

http://www.nature.com/articles/s41587-018-0011-0.pdf

Reference47 articles.

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2. Kim, H. K. et al. In vivo high-throughput profiling of CRISPR–Cpf1 activity. Nat. Methods 14, 153–159 (2017).

3. Gao, L. et al. Engineered Cpf1 variants with altered PAM specificities. Nat. Biotechnol. 35, 789–792 (2017).

4. Hsu, P. D., Lander, E. S. & Zhang, F. Development and applications of CRISPR–Cas9 for genome engineering. Cell 157, 1262–1278 (2014).

5. Dominguez, A. A., Lim, W. A. & Qi, L. S. Beyond editing: repurposing CRISPR–Cas9 for precision genome regulation and interrogation. Nat. Rev. Mol. Cell Biol. 17, 5–15 (2016).

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