Engineered CRISPRa System for Precise and Multiplex Gene Regulation Using a Hybrid dCas12a Variant and Hairpin-Spacer crRNAs-Reference-Cited by-同舟云学术

Engineered CRISPRa System for Precise and Multiplex Gene Regulation Using a Hybrid dCas12a Variant and Hairpin-Spacer crRNAs

Published:2024-02-02 Issue:6 Volume:96 Page:2637-2642
ISSN:0003-2700
Container-title:Analytical Chemistry
language:en
Short-container-title:Anal. Chem.

Author:

Ke Yuqing¹²,Zhang Shuang¹²,Gao Yingying¹²,Chen Xiaoxiang¹²,He Jie¹²,Chen Youming¹²,Zhang Qiang¹²,Ding Xianting¹²^ORCID

Affiliation:

1. Nantong First People’s Hospital and Nantong Hospital of Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Nantong 226006, P. R. China

2. State Key Laboratory of Oncogenes and Related Genes, Institute for Personalized Medicine, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, P. R. China

Funder

Shanghai Jiao Tong University

National Key Research and Development Program of China

Shanghai Municipal Education Commission

Science and Technology Commission of Shanghai Municipality

National Natural Science Foundation of China

Shanghai Municipal Health Commission

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.analchem.3c05318

Reference15 articles.

1. Genome editing with CRISPR–Cas nucleases, base editors, transposases and prime editors

2. Beyond editing: repurposing CRISPR–Cas9 for precision genome regulation and interrogation

3. Structural Basis for Guide RNA Processing and Seed-Dependent DNA Targeting by CRISPR-Cas12a

4. A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity

5. Structural Basis for the Canonical and Non-canonical PAM Recognition by CRISPR-Cpf1

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