Micronucleus is not a potent inducer of the cGAS/STING pathway
Author:
Affiliation:
1. Graduate School of Biostudies, Kyoto University
2. IFOM-KU Joint Research Laboratory, Graduate School of Medicine, Kyoto University
3. IFOM ETS, the AIRC Institute of Molecular Oncology, Milan, Italy
Abstract
Funder
MEXT | Japan Society for the Promotion of Science
Publisher
Life Science Alliance, LLC
Subject
Health, Toxicology and Mutagenesis,Plant Science,Biochemistry, Genetics and Molecular Biology (miscellaneous),Ecology
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1. Epigenetic dysregulation from chromosomal transit in micronuclei
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3. TBK1 and IKKε Act Redundantly to Mediate STING-Induced NF-κB Responses in Myeloid Cells
4. Termination of STING responses is mediated via ESCRT‐dependent degradation
5. Phosphoinositide Interactions Position cGAS at the Plasma Membrane to Ensure Efficient Distinction between Self- and Viral DNA
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