Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection
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Published:2018-02-26
Issue:3
Volume:50
Page:381-389
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ISSN:1061-4036
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Container-title:Nature Genetics
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language:en
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Short-container-title:Nat Genet
Author:
Pardiñas Antonio F.ORCID, , Holmans Peter, Pocklington Andrew J., Escott-Price Valentina, Ripke StephanORCID, Carrera Noa, Legge Sophie E.ORCID, Bishop Sophie, Cameron DarrenORCID, Hamshere Marian L., Han Jun, Hubbard Leon, Lynham AmyORCID, Mantripragada Kiran, Rees Elliott, MacCabe James H.ORCID, McCarroll Steven A., Baune Bernhard T.ORCID, Breen GeromeORCID, Byrne Enda M.ORCID, Dannlowski Udo, Eley Thalia C.ORCID, Hayward CarolineORCID, Martin Nicholas G., McIntosh Andrew M.ORCID, Plomin Robert, Porteous David J.ORCID, Wray Naomi R.ORCID, Caballero Armando, Geschwind Daniel H., Huckins Laura M.ORCID, Ruderfer Douglas M., Santiago EnriqueORCID, Sklar Pamela, Stahl Eli A., Won HyejungORCID, Agerbo EsbenORCID, Als Thomas D.ORCID, Andreassen Ole A., Bækvad-Hansen Marie, Mortensen Preben Bo, Pedersen Carsten Bøcker, Børglum Anders D., Bybjerg-Grauholm JonasORCID, Djurovic Srdjan, Durmishi Naser, Pedersen Marianne Giørtz, Golimbet Vera, Grove JakobORCID, Hougaard David M.ORCID, Mattheisen Manuel, Molden EspenORCID, Mors Ole, Nordentoft Merete, Pejovic-Milovancevic Milica, Sigurdsson EngilbertORCID, Silagadze Teimuraz, Hansen Christine SøholmORCID, Stefansson Kari, Stefansson Hreinn, Steinberg Stacy, Tosato SarahORCID, Werge Thomas, Collier David A.ORCID, Rujescu Dan, Kirov George, Owen Michael J.ORCID, O’Donovan Michael C.ORCID, Walters James T. R.ORCID,
Publisher
Springer Science and Business Media LLC
Reference105 articles.
1. Owen, M. J., Sawa, A. & Mortensen, P. B. Schizophrenia. Lancet 388, 86–97 (2016). 2. Thornicroft, G. Physical health disparities and mental illness: the scandal of premature mortality. Br. J. Psychiatry 199, 441–442 (2011). 3. Olfson, M., Gerhard, T., Huang, C., Crystal, S. & Stroup, T. S. Premature mortality among adults with schizophrenia in the United States. JAMA Psychiatry 72, 1172–1181 (2015). 4. Morgan, C. et al. Reappraising the long-term course and outcome of psychotic disorders: the AESOP-10 study. Psychol. Med. 44, 2713–2726 (2014). 5. Schizophrenia Working Group of the Psychiatric Genomics Consortium. Biological insights from 108 schizophrenia-associated genetic loci. Nature 511, 421–427 (2014).
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