Multi-ancestry genome-wide association analyses identify novel genetic mechanisms in rheumatoid arthritis
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Published:2022-11
Issue:11
Volume:54
Page:1640-1651
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ISSN:1061-4036
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Container-title:Nature Genetics
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language:en
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Short-container-title:Nat Genet
Author:
Ishigaki KazuyoshiORCID, Sakaue SaoriORCID, Terao ChikashiORCID, Luo YangORCID, Sonehara Kyuto, Yamaguchi KensukeORCID, Amariuta TiffanyORCID, Too Chun Lai, Laufer Vincent A., Scott Ian C.ORCID, Viatte SebastienORCID, Takahashi MeikoORCID, Ohmura Koichiro, Murasawa Akira, Hashimoto Motomu, Ito HiromuORCID, Hammoudeh Mohammed, Emadi Samar Al, Masri Basel K., Halabi HusseinORCID, Badsha Humeira, Uthman Imad W., Wu Xin, Lin Li, Li Ting, Plant DarrenORCID, Barton AnneORCID, Orozco GiselaORCID, Verstappen Suzanne M. M., Bowes JohnORCID, MacGregor Alexander J., Honda Suguru, Koido MasaruORCID, Tomizuka Kohei, Kamatani YoichiroORCID, Tanaka Hiroaki, Tanaka EiichiORCID, Suzuki Akari, Maeda Yuichi, Yamamoto KenichiORCID, Miyawaki Satoru, Xie Gang, Zhang Jinyi, Amos Christopher I.ORCID, Keystone Edward, Wolbink Gertjan, van der Horst-Bruinsma Irene, Cui Jing, Liao Katherine P.ORCID, Carroll Robert J., Lee Hye-Soon, Bang So-Young, Siminovitch Katherine A., de Vries NiekORCID, Alfredsson LarsORCID, Rantapää-Dahlqvist SolbrittORCID, Karlson Elizabeth W., Bae Sang-CheolORCID, Kimberly Robert P., Edberg Jeffrey C., Mariette XavierORCID, Huizinga TomORCID, Dieudé PhilippeORCID, Schneider Matthias, Kerick MartinORCID, Denny Joshua C., Matsuda KoichiORCID, Matsuo KeitaroORCID, Mimori Tsuneyo, Matsuda Fumihiko, Fujio Keishi, Tanaka YoshiyaORCID, Kumanogoh AtsushiORCID, Traylor Matthew, Lewis Cathryn M.ORCID, Eyre StephenORCID, Xu Huji, Saxena RichaORCID, Arayssi Thurayya, Kochi YutaORCID, Ikari KatsunoriORCID, Harigai MasayoshiORCID, Gregersen Peter K., Yamamoto Kazuhiko, Louis Bridges S., Padyukov LeonidORCID, Martin JavierORCID, Klareskog LarsORCID, Okada YukinoriORCID, Raychaudhuri SoumyaORCID,
Funder
Foundation for the National Institutes of Health
Publisher
Springer Science and Business Media LLC
Reference78 articles.
1. Ajeganova, S. & Huizinga, T. W. J. Seronegative and seropositive RA: alike but different? Nat. Rev. Rheumatol. 11, 8–9 (2015). 2. Okada, Y. et al. Genetics of rheumatoid arthritis contributes to biology and drug discovery. Nature 506, 376–381 (2014). 3. Ishigaki, K. et al. Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases. Nat. Genet. 52, 669–679 (2020). 4. MacGregor, A. J. et al. Characterizing the quantitative genetic contribution to rheumatoid arthritis using data from twins. Arthritis Rheum. 43, 30–37 (2000). 5. Ishigaki, K. et al. Polygenic burdens on cell-specific pathways underlie the risk of rheumatoid arthritis. Nat. Genet. 49, 1120–1125 (2017).
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