Overcoming mTOR resistance mutations with a new-generation mTOR inhibitor-Reference-Cited by-同舟云学术

Overcoming mTOR resistance mutations with a new-generation mTOR inhibitor

Published:2016-05-18 Issue:7606 Volume:534 Page:272-276
ISSN:0028-0836
Container-title:Nature
language:en
Short-container-title:Nature

Author:

Rodrik-Outmezguine Vanessa S.,Okaniwa Masanori,Yao Zhan,Novotny Chris J.,McWhirter Claire,Banaji Arpitha,Won Helen,Wong Wai,Berger Mike,de Stanchina Elisa,Barratt Derek G.,Cosulich Sabina,Klinowska Teresa,Rosen Neal,Shokat Kevan M.

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/nature17963.pdf

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3. Iyer, G. et al. Genome sequencing identifies a basis for everolimus sensitivity. Science 338, 221 (2012)

4. Wagle, N. et al. Activating mTOR mutations in a patient with an extraordinary response on a phase I trial of everolimus and pazopanib. Cancer Discov . 4, 546–553 (2014)

5. Wagle, N. et al. Response and acquired resistance to everolimus in anaplastic thyroid cancer. N. Engl. J. Med. 371, 1426–1433 (2014)

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