Genome Sequencing Identifies a Basis for Everolimus Sensitivity-Reference-Cited by-同舟云学术

Genome Sequencing Identifies a Basis for Everolimus Sensitivity

Published:2012-10-12 Issue:6104 Volume:338 Page:221-221
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Iyer Gopa¹²³,Hanrahan Aphrothiti J.¹,Milowsky Matthew I.²³,Al-Ahmadie Hikmat⁴,Scott Sasinya N.¹,Janakiraman Manickam¹,Pirun Mono⁵,Sander Chris⁵,Socci Nicholas D.⁶,Ostrovnaya Irina⁷,Viale Agnes⁸,Heguy Adriana¹,Peng Luke¹,Chan Timothy A.¹,Bochner Bernard⁹,Bajorin Dean F.²³,Berger Michael F.⁴,Taylor Barry S.⁵,Solit David B.¹²³

Affiliation:

1. Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

2. Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

3. Department of Medicine, Weill Medical College of Cornell University, New York, NY 10065, USA.

4. Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

5. Computational Biology, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

6. Bioinformatics Core Laboratory, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

7. Department of Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

8. Genomics Core Laboratory, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

9. Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

Abstract

Tumor genome sequencing reveals the molecular basis of a patient’s unexpected and dramatic response to a cancer drug.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference20 articles.

1. Loss of the Tumor Suppressor GeneNF2, Encoding Merlin, Constitutively Activates Integrin-Dependent mTORC1 Signaling

2. Spectrum of Phosphatidylinositol 3-Kinase Pathway Gene Alterations in Bladder Cancer

3. Everolimus for Subependymal Giant-Cell Astrocytomas in Tuberous Sclerosis

4. A framework for variation discovery and genotyping using next-generation DNA sequencing data

5. The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data

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