The phosphatidylinositol 3-Kinase–AKT pathway in human cancer
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Earth and Planetary Sciences,General Environmental Science
Link
http://www.nature.com/articles/nrc839.pdf
Reference156 articles.
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3. Inukai, K. et al. p85α gene generates three isoforms of regulatory subunit for phosphatidylinositol 3-kinase p50α, p55α, and p85α, with different PI 3-kinase activity elevating responses to insulin. J. Biol. Chem. 272, 7873–7882 (1997).
4. Kaliman, P. et al. Insulin-like growth factors require phosphatidylinositol 3-kinase to signal myogenesis: dominant negative p85 expression blocks differentiation of L6E9 muscle cells. Mol. Endocrinol. 12, 66–77(1998).
5. Ueki, K., Algenstaedt, P., Mauvais-Jarvis, F. & Kahn, C. R. Positive and negative regulation of phosphoinositide 3-kinase-dependent signaling pathways by three different gene products of the p85 α regulatory subunit. Mol. Cell. Biol. 20, 8035–8046 (2000).
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