Physiological and pathological roles of lipogenesis
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Physiology (medical),Endocrinology, Diabetes and Metabolism,Internal Medicine
Link
https://www.nature.com/articles/s42255-023-00786-y.pdf
Reference382 articles.
1. Yoon, H., Shaw, J. L., Haigis, M. C. & Greka, A. Lipid metabolism in sickness and in health: emerging regulators of lipotoxicity. Mol. Cell 81, 3708–3730 (2021).
2. Batchuluun, B., Pinkosky, S. L. & Steinberg, G. R. Lipogenesis inhibitors: therapeutic opportunities and challenges. Nat. Rev. Drug Discov. 21, 283–305 (2022).
3. Wang, Y., Viscarra, J., Kim, S. J. & Sul, H. S. Transcriptional regulation of hepatic lipogenesis. Nat. Rev. Mol. Cell Biol. 16, 678–689 (2015).
4. Grabner, G. F., Xie, H., Schweiger, M. & Zechner, R. Lipolysis: cellular mechanisms for lipid mobilization from fat stores. Nat. Metab. 3, 1445–1465 (2021).
5. Zhang, Z. et al. Serine catabolism generates liver NADPH and supports hepatic lipogenesis. Nat. Metab. 3, 1608–1620 (2021). The authors show that adipose de novo lipogenesis is supported by glucose, and the pentose phosphate pathway provides NADPH, while hepatic lipogenesis mainly uses acetate and lactate, with NADPH generated by folate-mediated serine catabolism.
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