Lipogenesis inhibitors: therapeutic opportunities and challenges
Author:
Publisher
Springer Science and Business Media LLC
Subject
Drug Discovery,Pharmacology,General Medicine
Link
https://www.nature.com/articles/s41573-021-00367-2.pdf
Reference300 articles.
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3. Ference, B. A. et al. Mendelian randomization study of ACLY and cardiovascular disease. N. Engl. J. Med. 380, 1033–1042 (2019). Demonstrates that genetic variants that mimic ACLY inhibitors and statins lower plasma LDL in humans by the same mechanism of action.
4. Lawitz, E. J. et al. Acetyl-CoA carboxylase inhibitor GS-0976 for 12 weeks reduces hepatic de novo lipogenesis and steatosis in patients with nonalcoholic steatohepatitis. Clin. Gastroenterol. Hepatol. 16, 1983–1991.e3 (2018).
5. Smith, G. I. et al. Insulin resistance drives hepatic de novo lipogenesis in nonalcoholic fatty liver disease. J. Clin. Invest. 130, 1453–1460 (2020).
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