Body weight regulation via MT1-MMP-mediated cleavage of GFRAL-Reference-Cited by-同舟云学术

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Body weight regulation via MT1-MMP-mediated cleavage of GFRAL

Published:2022-02-17 Issue:2 Volume:4 Page:203-212
ISSN:2522-5812
Container-title:Nature Metabolism
language:en
Short-container-title:Nat Metab

Author:

Chow Chi Fung Willis^ORCID,Guo Xuanming^ORCID,Asthana Pallavi,Zhang Shuo,Wong Sheung Kin Ken,Fallah Samane,Che Sijia,Gurung Susma,Wang Zening^ORCID,Lee Ki Baek,Ge Xin^ORCID,Yuan Shiyang,Xu Haoyu,Ip Jacque Pak Kan^ORCID,Jiang Zhixin,Zhai Lixiang,Wu Jiayan,Zhang Yijing,Mahato Arun Kumar^ORCID,Saarma Mart^ORCID,Lin Cheng Yuan,Kwan Hiu Yee^ORCID,Huang Tao,Lyu Aiping^ORCID,Zhou Zhongjun^ORCID,Bian Zhao-Xiang^ORCID,Wong Hoi Leong Xavier^ORCID

Funder

Research Grants Council, University Grants Committee

Food and Health Bureau of the Government of the Hong Kong Special Administrative Region | Health and Medical Research Fund

National Natural Science Foundation of China

Natural Science Foundation of Guangdong Province

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Physiology (medical),Endocrinology, Diabetes and Metabolism,Internal Medicine

Link

https://www.nature.com/articles/s42255-022-00529-5.pdf

Reference37 articles.

1. Xiong, Y. et al. Long-acting MIC-1/GDF15 molecules to treat obesity: evidence from mice to monkeys. Sci. Transl. Med. https://doi.org/10.1126/scitranslmed.aan8732 (2017).

2. Johnen, H. et al. Tumor-induced anorexia and weight loss are mediated by the TGF-β superfamily cytokine MIC-1. Nat. Med. 13, 1333–1340 (2007).

3. Tsai, V. W. W., Lin, S., Brown, D. A., Salis, A. & Breit, S. N. Anorexia-cachexia and obesity treatment may be two sides of the same coin: role of the TGF-β superfamily cytokine MIC-1/GDF15. Int. J. Obes. 40, 193–197 (2016).

4. Chrysovergis, K. et al. NAG-1/GDF-15 prevents obesity by increasing thermogenesis, lipolysis and oxidative metabolism. Int. J. Obes. 38, 1555–1564 (2014).

5. Macia, L. et al. Macrophage inhibitory cytokine 1 (MIC-1/GDF15) decreases food intake, body weight and improves glucose tolerance in mice on normal and obesogenic diets. PLoS ONE https://doi.org/10.1371/journal.pone.0034868 (2012).

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1. CCZ1 Accelerates the Progression of Cervical Squamous Cell Carcinoma by Promoting MMP2/MMP17 Expression;Biomedicines;2024-07-03

2. Overview of growth differentiation factor 15 (GDF15) in metabolic diseases;Biomedicine & Pharmacotherapy;2024-07

3. Preventing obesity, insulin resistance and type 2 diabetes by targeting MT1-MMP;Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease;2024-04

4. GDF15 activates AMPK and inhibits gluconeogenesis and fibrosis in the liver by attenuating the TGF-β1/SMAD3 pathway;Metabolism;2024-03

5. Artesunate treats obesity in male mice and non-human primates through GDF15/GFRAL signalling axis;Nature Communications;2024-02-03

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