Identification of a leucine-mediated threshold effect governing macrophage mTOR signalling and cardiovascular risk-Reference-Cited by-同舟云学术

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Identification of a leucine-mediated threshold effect governing macrophage mTOR signalling and cardiovascular risk

Published:2024-02-19 Issue:2 Volume:6 Page:359-377
ISSN:2522-5812
Container-title:Nature Metabolism
language:en
Short-container-title:Nat Metab

Author:

Zhang Xiangyu^ORCID,Kapoor Divya,Jeong Se-Jin,Fappi Alan^ORCID,Stitham Jeremiah,Shabrish Vasavi^ORCID,Sergin Ismail^ORCID,Yousif Eman,Rodriguez-Velez Astrid^ORCID,Yeh Yu-Sheng^ORCID,Park Arick^ORCID,Yurdagul Arif,Rom Oren^ORCID,Epelman Slava^ORCID,Schilling Joel D.^ORCID,Sardiello Marco^ORCID,Diwan Abhinav^ORCID,Cho Jaehyung^ORCID,Stitziel Nathan O.^ORCID,Javaheri Ali,Lodhi Irfan J.^ORCID,Mittendorfer Bettina^ORCID,Razani Babak^ORCID

Funder

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute

U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

U.S. Department of Veterans Affairs

Institute of Clinical and Translational Sciences

American Diabetes Association

U.S. Department of Health & Human Services | National Institutes of Health

American Heart Association

Longer Life Foundation

Publisher

Springer Science and Business Media LLC

Link

https://www.nature.com/articles/s42255-024-00984-2.pdf

Reference70 articles.

1. Fan, J. et al. Rabbit models for the study of human atherosclerosis: from pathophysiological mechanisms to translational medicine. Pharmacol. Ther. 146, 104–119 (2015).

2. Debry, G. Dietary Proteins and Atherosclerosis 1st edn https://doi.org/10.1201/9780203009307 (Taylor & Francis, 2003).

3. Zhang, X. et al. High-protein diets increase cardiovascular risk by activating macrophage mTOR to suppress mitophagy. Nat. Metab. 2, 110–125 (2020).

4. Wolfson, R. L. et al. Sestrin2 is a leucine sensor for the mTORC1 pathway. Science 351, 43–48 (2016).

5. Saxton, R. A., Chantranupong, L., Knockenhauer, K. E., Schwartz, T. U. & Sabatini, D. M. Mechanism of arginine sensing by CASTOR1 upstream of mTORC1. Nature 536, 229–233 (2016).

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5. A leucine–macrophage mTORC1 connection drives increased risk of atherosclerosis with high-protein diets;Nature Metabolism;2024-02-19

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