Serum antibodies to HIV-1 are produced post-measles virus infection: evidence for cross-reactivity with HLA

Author:

Baskar P V1,Collins G D1,Dorsey-Cooper B A1,Pyle R S1,Nagel J E1,Dwyer D2,Dunston G3,Johnson C E4,Kendig N1,Israel E2,Nalin D R5,Adler W H1

Affiliation:

1. Laboratory of Immunology, National Institute on Aging, NIH

2. Maryland State Health Department, Baltimore, MD

3. Howard University School of Medicine, Washington, DC

4. Case Western Reserve University School of Medicine, Cleveland OH

5. Merck Research Laboratories, West Point, PA, USA

Abstract

SUMMARY Convalescent sera obtained from patients who were recently recovered from an acute measles virus infection were tested for the presence of anti-HIV-1 antibodies by Western blot analysis. While 16% (17/104) of control sera displayed reactive bands to a variety of HIV proteins, 62% (45/73) of convalescent sera demonstrated immunoreactive bands corresponding to HIV-1 Pol and Gag, but not Env antigens. This cross-reactivity appears to be the result of an active measles infection. No HIV-1 immunoblot reactivity (0/10) was observed in sera obtained from young adults several weeks after a combined measles, mumps, and rubella (MMR) vaccination. Interestingly, examination of anti-HLA typing sera specific for either class I and class II molecules revealed that 46% (19/41) of these sera contained cross-reactive antibodies to HIV-1 proteins. Absorption of measles sera with mixed lymphocyte reaction (MLR)-activated lymphocytes and/or HIV-1 recombinant proteins significantly decreased or removed the presence of these HIV-1-immunoreactive antibodies. Together, these findings suggest that the immune response to a natural measles virus infection results in the production of antibodies to HIV-1 and possibly autoantigens.

Publisher

Oxford University Press (OUP)

Subject

Immunology,Immunology and Allergy

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