Variability in P-Glycoprotein Inhibitory Potency (IC50) Using Various in Vitro Experimental Systems: Implications for Universal Digoxin Drug-Drug Interaction Risk Assessment Decision Criteria-Reference-Cited by-同舟云学术

Variability in P-Glycoprotein Inhibitory Potency (IC50) Using Various in Vitro Experimental Systems: Implications for Universal Digoxin Drug-Drug Interaction Risk Assessment Decision Criteria

Published:2013-04-25 Issue:7 Volume:41 Page:1347-1366
ISSN:0090-9556
Container-title:Drug Metabolism and Disposition
language:en
Short-container-title:Drug Metab Dispos

Author:

Bentz Joe,O’Connor Michael P.,Bednarczyk Dallas,Coleman JoAnn,Lee Caroline,Palm Johan,Pak Y. Anne,Perloff Elke S.,Reyner Eric,Balimane Praveen,Brännström Marie,Chu Xiaoyan,Funk Christoph,Guo Ailan,Hanna Imad,Herédi-Szabó Krisztina,Hillgren Kate,Li Libin,Hollnack-Pusch Evelyn,Jamei Masoud,Lin Xuena,Mason Andrew K.,Neuhoff Sibylle,Patel Aarti,Podila Lalitha,Plise Emile,Rajaraman Ganesh,Salphati Laurent,Sands Eric,Taub Mitchell E.,Taur Jan-Shiang,Weitz Dietmar,Wortelboer Heleen M.,Xia Cindy Q.,Xiao Guangqing,Yabut Jocelyn,Yamagata Tetsuo,Zhang Lei,Ellens Harma

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

Reference34 articles.

1. Kinetic Identification of Membrane Transporters That Assist P-glycoprotein-Mediated Transport of Digoxin and Loperamide through a Confluent Monolayer of MDCKII-hMDR1 Cells

2. Agarwal S, Arya V, and Zhang L (2013). Review of P-gp inhibition data in recently approved new drug applications: utility of the proposed [I1]/IC50 and [I2]/IC50 criteria in the P-gp decision tree. J Cin Pharmacol 53:228–233.

3. Fitting the Elementary Rate Constants of the P-gp Transporter Network in the hMDR1-MDCK Confluent Cell Monolayer Using a Particle Swarm Algorithm

4. P-gp Inhibition Potential in Cell-Based Models: Which “Calculation” Method is the Most Accurate?

5. Do cell culture conditions influence the carrier-mediated transport of peptides in Caco-2 cell monolayers?

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