Kinetic Identification of Membrane Transporters That Assist P-glycoprotein-Mediated Transport of Digoxin and Loperamide through a Confluent Monolayer of MDCKII-hMDR1 Cells-Reference-Cited by-同舟云学术

Kinetic Identification of Membrane Transporters That Assist P-glycoprotein-Mediated Transport of Digoxin and Loperamide through a Confluent Monolayer of MDCKII-hMDR1 Cells

Published:2007-10-29 Issue:2 Volume:36 Page:452-460
ISSN:0090-9556
Container-title:Drug Metabolism and Disposition
language:en
Short-container-title:Drug Metab Dispos

Author:

Acharya Poulomi,O'Connor Michael P.,Polli Joseph W.,Ayrton Andrew,Ellens Harma,Bentz Joe

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

Reference39 articles.

1. P-Glycoprotein (P-gp) Expressed in a Confluent Monolayer of hMDR1−MDCKII Cells Has More Than One Efflux Pathway with Cooperative Binding Sites

2. Data-Based Mathematical Modeling of Vectorial Transport across Double-Transfected Polarized Cells

3. The Steady-State Michaelis–Menten Analysis of P-Glycoprotein Mediated Transport Through a Confluent Cell Monolayer Cannot Predict the Correct Michaelis Constant Km

4. Comparison of P-glycoprotein-mediated drug–digoxin interactions in Caco-2 with human and rodent intestine: Relevance to in vivo prediction

5. The Human ATP-Binding Cassette (ABC) Transporter Superfamily

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