Bis-6-amidino-benzothiazole Derivative that Cures Experimental Stage 1 African Trypanosomiasis with a Single Dose-Reference-Cited by-同舟云学术

Bis-6-amidino-benzothiazole Derivative that Cures Experimental Stage 1 African Trypanosomiasis with a Single Dose

Published:2023-09-18 Issue:18 Volume:66 Page:13043-13057
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Racané Livio¹,Ptiček Lucija¹,Kostrun Sanja²,Raić-Malić Silvana³,Taylor Martin Craig⁴^ORCID,Delves Michael⁴^ORCID,Alsford Sam⁴,Olmo Francisco⁴,Francisco Amanda Fortes⁴,Kelly John M.⁴^ORCID

Affiliation:

1. Department of Applied Chemistry, Faculty of Textile Technology, University of Zagreb, Prilaz baruna Filipovića 28a, 10000 Zagreb, Croatia

2. Chemistry Department, Selvita Ltd., Prilaz baruna Filipovića 29, 10000 Zagreb, Croatia

3. Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Marulićev trg 20, 10000 Zagreb, Croatia

4. Department of Infection Biology, London School of Hygiene and Tropical Medicine, Keppel Street, WC1E 7HT London, U.K.

Funder

Medical Research Council

Hrvatska Zaklada za Znanost

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c01051

Reference72 articles.

1. World Health Organization. Trypanosomiasis, Human African (Sleeping Sickness), 2022. https://www.who.int/news-room/fact-sheets/detail/trypanosomiasis-human-african-(sleeping-sickness).

2. Combatting African Animal Trypanosomiasis (AAT) in livestock: The potential role of trypanotolerance

3. Adipose Tissue: A Safe Haven for Parasites?

4. Thinking outside the blood: Perspectives on tissue-resident Trypanosoma brucei

5. An Update on African Trypanocide Pharmaceutics and Resistance