Initial Pharmacological Characterization of a Major Hydroxy Metabolite of PF-5190457: Inverse Agonist Activity of PF-6870961 at the Ghrelin Receptor-Reference-Cited by-同舟云学术

Initial Pharmacological Characterization of a Major Hydroxy Metabolite of PF-5190457: Inverse Agonist Activity of PF-6870961 at the Ghrelin Receptor

Published:2023-01-11 Issue:2 Volume:386 Page:117-128
ISSN:0022-3565
Container-title:Journal of Pharmacology and Experimental Therapeutics
language:en
Short-container-title:J Pharmacol Exp Ther

Author:

Deschaine Sara L.,Hedegaard Morten A.,Pince Claire L.,Farokhnia Mehdi,Moose Jacob E.,Stock Ingrid A.,Adusumalli Sravani,Akhlaghi Fatemeh,Hougland James L.,Sulima Agnieszka,Rice Kenner C.,Koob George F.,Vendruscolo Leandro F.,Holst Birgitte,Leggio Lorenzo

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmacology,Molecular Medicine

Reference38 articles.

1. Development and validation of an assay for a novel ghrelin receptor inverse agonist PF-5190457 and its major hydroxy metabolite (PF-6870961) by LC-MS/MS in human plasma;Adusumalli;J Chromatogr B Analyt Technol Biomed Life Sci,2019

2. Role of Molybdenum-Containing Enzymes in the Biotransformation of the Novel Ghrelin Receptor Inverse Agonist PF-5190457: A Reverse Translational Bed-to-Bench Approach

3. Ghrelin and food reward

4. Discovery of PF-5190457, a Potent, Selective, and Orally Bioavailable Ghrelin Receptor Inverse Agonist Clinical Candidate

5. Structure–Activity Analysis of Human Ghrelin O-Acyltransferase Reveals Chemical Determinants of Ghrelin Selectivity and Acyl Group Recognition

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