Discovery of PF-5190457, a Potent, Selective, and Orally Bioavailable Ghrelin Receptor Inverse Agonist Clinical Candidate-Reference-Cited by-同舟云学术

Discovery of PF-5190457, a Potent, Selective, and Orally Bioavailable Ghrelin Receptor Inverse Agonist Clinical Candidate

Published:2014-02-24 Issue:5 Volume:5 Page:474-479
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Bhattacharya Samit K.¹,Andrews Kim¹,Beveridge Ramsay¹,Cameron Kimberly O.¹,Chen Chiliu¹,Dunn Matthew¹,Fernando Dilinie¹,Gao Hua¹,Hepworth David¹,Jackson V. Margaret¹,Khot Vishal¹,Kong Jimmy¹,Kosa Rachel E.¹,Lapham Kimberly¹,Loria Paula M.¹,Londregan Allyn T.¹,McClure Kim F.¹,Orr Suvi T. M.¹,Patel Jigna¹,Rose Colin¹,Saenz James¹,Stock Ingrid A.¹,Storer Gregory¹,VanVolkenburg Maria¹,Vrieze Derek¹,Wang Guoqiang¹,Xiao Jun¹,Zhang Yingxin¹

Affiliation:

1. Worldwide Medicinal Chemistry, ‡Cardiovascular and Metabolic Research Unit, §Pharmacokinetics, Dynamics, and Metabolism, ∥Primary Pharmacology Group, and ⊥Pharmaceutical Sciences, Pfizer Global Research and Development, 620 Memorial Drive, Cambridge, Massachusetts 02139, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/ml400473x

Reference43 articles.

1. IDF Diabetes Atlas.http://www.diabetesatlas.org.

2. New Perspectives into the Molecular Pathogenesis and Treatment of Type 2 Diabetes

3. Ghrelin receptor.http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?familyId=28&objectId=246&familyType=RECEPTOR.

4. Ghrelin Suppresses Glucose-Stimulated Insulin Secretion and Deteriorates Glucose Tolerance in Healthy Humans

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