EMPIRICAL VALIDATION OF A RAT IN VITRO ORGAN SLICE MODEL AS A TOOL FOR IN VIVO CLEARANCE PREDICTION-Reference-Cited by-同舟云学术

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EMPIRICAL VALIDATION OF A RAT IN VITRO ORGAN SLICE MODEL AS A TOOL FOR IN VIVO CLEARANCE PREDICTION

Published:2006-01-13 Issue:4 Volume:34 Page:591-599
ISSN:0090-9556
Container-title:Drug Metabolism and Disposition
language:en
Short-container-title:Drug Metab Dispos

Author:

de Graaf Inge A. M.,de Kanter Ruben,de Jager Marina H.,Camacho Raquel,Langenkamp Elise,van de Kerkhof Esther G.,Groothuis Geny M. M.

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

Reference41 articles.

1. [43] Measurement of steroid hydroxylation reactions by high-performance liquid chromatography as indicator of P450 identity and function

2. Prediction of in vivo hepatic clearance from in vitro data using cryopreserved human hepatocytes

3. 7-EthoxycoumarinO-deethylase kinetics in isolated rat, dog and human hepatocyte suspensions

4. Impact of serum on clearance predictions obtained from suspensions and primary cultures of rat hepatocytes

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