Clearance Prediction of Targeted Covalent Inhibitors by In Vitro-In Vivo Extrapolation of Hepatic and Extrahepatic Clearance Mechanisms-Reference-Cited by-同舟云学术

Clearance Prediction of Targeted Covalent Inhibitors by In Vitro-In Vivo Extrapolation of Hepatic and Extrahepatic Clearance Mechanisms

Published:2016-10-26 Issue:1 Volume:45 Page:1-7
ISSN:0090-9556
Container-title:Drug Metabolism and Disposition
language:en
Short-container-title:Drug Metab Dispos

Author:

Leung Louis,Yang Xin,Strelevitz Timothy J.,Montgomery Justin,Brown Matthew F.,Zientek Michael A.,Banfield Christopher,Gilbert Adam M.,Thorarensen Atli,Dowty Martin E.

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

Reference24 articles.

1. Human glutathione S-transferases

2. Can In Vitro Metabolism-Dependent Covalent Binding Data Distinguish Hepatotoxic from Nonhepatotoxic Drugs? An Analysis Using Human Hepatocytes and Liver S-9 Fraction

3. Enzymes and transport systems involved in the formation and disposition of glutathione S-conjugates. Role in bioactivation and detoxication mechanisms of xenobiotics;Commandeur;Pharmacol Rev,1995

4. Benchmarking in Vitro Covalent Binding Burden As a Tool To Assess Potential Toxicity Caused by Nonspecific Covalent Binding of Covalent Drugs

Cited by 35 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Predicting the Intravenous Pharmacokinetics of Covalent Drugs in Animals and Humans;Journal of Medicinal Chemistry;2024-07-17

2. Emerging and Re-emerging Warheads for Targeted Covalent Inhibitors: An Update;Journal of Medicinal Chemistry;2024-05-07

3. Virtual Bioequivalence Assessment of Ritlecitinib Capsules with Incorporation of Observed Clinical Variability Using a Physiologically Based Pharmacokinetic Model;The AAPS Journal;2024-01-24

4. A New Dawn for Targeted Cancer Therapy: Small Molecule Covalent Binding Inhibitor Targeting K-Ras (G12C);Current Medicinal Chemistry;2023-11-02

5. Recent advances in the development of inhibitors targeting KRAS-G12C and its related pathways;European Journal of Medicinal Chemistry;2023-11