Can In Vitro Metabolism-Dependent Covalent Binding Data Distinguish Hepatotoxic from Nonhepatotoxic Drugs? An Analysis Using Human Hepatocytes and Liver S-9 Fraction-Reference-Cited by-同舟云学术

Can In Vitro Metabolism-Dependent Covalent Binding Data Distinguish Hepatotoxic from Nonhepatotoxic Drugs? An Analysis Using Human Hepatocytes and Liver S-9 Fraction

Published:2009-01-22 Issue:2 Volume:22 Page:332-340
ISSN:0893-228X
Container-title:Chemical Research in Toxicology
language:en
Short-container-title:Chem. Res. Toxicol.

Author:

Bauman Jonathon N.¹,Kelly Joan M.¹,Tripathy Sakambari¹,Zhao Sabrina X.¹,Lam Wing W.¹,Kalgutkar Amit S.¹,Obach R. Scott¹

Affiliation:

1. Pharmacokinetics, Dynamics and Metabolism Department, Pfizer Global Research and Development, Groton, Connecticut 06340, and Pfizer Research Technology Center, Cambridge, Massachusetts 02139

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/tx800407w

Reference32 articles.

1. Drug-Induced Liver Injury

2. Is it Possible to More Accurately Predict which Drug Candidates will cause Idiosyncratic Drug Reactions

3. Animal models of idiosyncratic drug reactions

4. Investigations toward enhanced understanding of hepatic idiosyncratic drug reactions

5. Mechanism of Idiosyncratic Drug Reactions: Reactive Metabolites Formation, Protein Binding and the Regulation of the Immune System

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