Benchmarking in Vitro Covalent Binding Burden As a Tool To Assess Potential Toxicity Caused by Nonspecific Covalent Binding of Covalent Drugs
Author:
Affiliation:
1. Pharmacokinetics, Dynamics and Metabolism and ‡Worldwide Medicinal Chemistry, Pfizer Inc., Groton, Connecticut 06340, United States
Publisher
American Chemical Society (ACS)
Subject
Toxicology,General Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/tx400301q
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1. Strategies for discovering and derisking covalent, irreversible enzyme inhibitors
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