Intrinsic Clearance Assay Incubational Binding: A Method Comparison-Reference-Cited by-同舟云学术

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Intrinsic Clearance Assay Incubational Binding: A Method Comparison

Published:2017-01-25 Issue:4 Volume:45 Page:342-345
ISSN:0090-9556
Container-title:Drug Metabolism and Disposition
language:en
Short-container-title:Drug Metab Dispos

Author:

Chen Sofia,Prieto Garcia Luna,Bergström Fredrik,Nordell Pär,Grime Ken

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

Reference16 articles.

1. The effect of ionized species on microsomal binding

2. The Influence of Nonspecific Microsomal Binding on Apparent Intrinsic Clearance, and Its Prediction from Physicochemical Properties

3. THE BINDING OF DRUGS TO HEPATOCYTES AND ITS RELATIONSHIP TO PHYSICOCHEMICAL PROPERTIES

4. Assessment ofin silicomodels for fraction of unbound drug in human liver microsomes

5. In Silico Modeling of Nonspecific Binding to Human Liver Microsomes

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1. Comparison of Commonly Used and New Methods to Determine Small Molecule Non-Specific Binding to Human Liver Microsomes;Journal of Pharmaceutical Sciences;2024-04

2. Prediction of the Time to Reach Equilibrium for Improved Estimation of the Unbound Fraction of Compounds in Equilibrium Dialysis Using kinetic Modeling;Journal of Pharmaceutical Sciences;2023-11

3. In vitro–in vivo extrapolation of bexarotene metabolism in the presence of chronic kidney disease and acute kidney injury in rat using physiologically based pharmacokinetic modeling and extrapolation to human;Biopharmaceutics & Drug Disposition;2022-11-21

4. Non-specific binding of compounds in in vitro metabolism assays: a comparison of microsomal and hepatocyte binding in different species and an assessment of the accuracy of prediction models;Xenobiotica;2022-08-03

5. Application of Empirical Scalars To Enable Early Prediction of Human Hepatic Clearance Using In Vitro-In Vivo Extrapolation in Drug Discovery: An Evaluation of 173 Drugs;Drug Metabolism and Disposition;2022-05-30

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