Comparison of Commonly Used and New Methods to Determine Small Molecule Non-Specific Binding to Human Liver Microsomes

Author:

Wang TingORCID,Whitcher-Johnstone Andrea,Scaringella Young_Sun,Keith-Luzzi MonicaORCID,Shao Juntang,Taub Mitchell E.,Chan Tom S.ORCID

Publisher

Elsevier BV

Reference24 articles.

1. Role of human liver microsomes in in vitro metabolism of drugs—a review;Asha;Appl Biochem Biotechnol,2010

2. Nonspecific binding of drugs to human liver microsomes;McLure;Brit J Clin Pharmaco,2000

3. Intrinsic clearance assay incubational binding: a method comparison;Chen;Drug Metab Dispos,2017

4. Prediction of human clearance of twenty-nine drugs from hepatic microsomal intrinsic clearance data: an examination of in vitro half-life approach and nonspecific binding to microsomes;Obach;Drug Metab Dispos,1999

5. Prediction of the time to reach equilibrium for improved estimation of the unbound fraction of compounds in equilibrium dialysis using kinetic modeling;Bae;J Pharm Sci,2023

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