The effect of ionized species on microsomal binding-Reference-Cited by-同舟云学术

The effect of ionized species on microsomal binding

Published:2012-01 Issue: Volume:47 Page:202-205
ISSN:0223-5234
Container-title:European Journal of Medicinal Chemistry
language:en
Short-container-title:European Journal of Medicinal Chemistry

Author:

Abraham Michael H.,Austin Rupert P.

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference21 articles.

1. The importance of nonspecific binding in in vitro matrices, its impact on enzyme kinetic studies of drug metabolism and implications for in vitro–in vivo correlations;Obach;Drug Metab. Dispos.,1996

2. Assessment of in silico models for fraction of unbound drug in human liver microsomes;Gao;Expert Opin. Drug Metab. Toxicol.,2010

3. The influence of nonspecific microsomal binding on apparent intrinsic clearance, and its prediction from physicochemical properties;Austin;Drug Metab. Dispos.,2002

4. Binding of drugs to hepatic microsomes: comment and assessment of current prediction methodology with recommendation for improvement;Hallifax;Drug Metab. Dispos.,2006

5. In silico modeling of nonspecific binding to human liver microsomes;Gao;Drug Metab. Dispos.,2008

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